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An avian influenza A (H7N9) virus vaccine candidate based on the fusion protein of hemagglutinin globular head and Salmonella typhimurium flagellin.

BMC Biotechnol.. 2015; 
SongLi,XiongDan,KangXilong,YangYun,WangJing,GuoYaxin,XuHui,ChenSujuan,PengDaxin,PanZhiming,JiaoX
Products/Services Used Details Operation
Custom Vector Construction Both HA1-2 and HA1-2-fliC PCR products were cloned into the pCold vectors (Takara, Dalian, China), after being digested by SacI/HindIII or EcoRI/XbaI in advance, generating the constructs pCold-HA1-2 and pCold-HA1-2-fliC, respectively. The resulting constructs were confirmed via DNA sequencing by Genscript (Nanjing, China). Get A Quote

摘要

A novel influenza virus, subtype H7N9, circulated through China in 2013-2014. Its higher rates of human infection in a wide range of locations within China and the associated increased likelihood of human-to-human transmission have caused global concern. Recombinant subunit vaccines provide safe and targeted protection against viral infections. However, the protective efficacy of recombinant subunit vaccines tends to be less potent than vaccines made from whole viruses. Studies have shown that bacterial flagellin has strong adjuvant activity and induces protective immune responses.

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