Non-small cell lung cancer (NSCLC) is one of the most common aggressive malignancies. miRNAs have been identified as important biomarkers and regulators of NSCLC. However， the functional contributions of miR-1260b to NSCLC cell proliferation and apoptosis have not been studied. In this study， miR-1260b was upregulated in NSCLC plasma， tissues， and cell lines， and its high expression was correlated with tumor size and progression. Functionally， miR-1260b overexpression promoted cell proliferation and cell cycle， conversely inhibited cell apoptosis and senescence. Mechanically， miR-1260b negatively regulated SOCS6 by directly binding to its 3'-UTR. Furthermore， miR-1260b-mediated suppression of ... More
Non-small cell lung cancer (NSCLC) is one of the most common aggressive malignancies. miRNAs have been identified as important biomarkers and regulators of NSCLC. However， the functional contributions of miR-1260b to NSCLC cell proliferation and apoptosis have not been studied. In this study， miR-1260b was upregulated in NSCLC plasma， tissues， and cell lines， and its high expression was correlated with tumor size and progression. Functionally， miR-1260b overexpression promoted cell proliferation and cell cycle， conversely inhibited cell apoptosis and senescence. Mechanically， miR-1260b negatively regulated SOCS6 by directly binding to its 3'-UTR. Furthermore， miR-1260b-mediated suppression of SOCS6 activated KIT signaling. Moreover， YY1 was an upstream regulator of miR-1260b. This study is the first to illustrate that miR-1260b， mediated by YY1， activates KIT signaling by targeting SOCS6 to regulate NSCLC cell proliferation and apoptosis， and is a potential biomarker and therapeutic target for NSCLC. In sum， our work provides new insights into the molecular mechanisms of NSCLC involved in cell proliferation and apoptosis.
