至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Recycling endosomal CD133 functions as an inhibitor of autophagy at the pericentrosomal region.

Sci Rep. 2019-02; 
IzumiHideki,LiYuanyuan,ShibakiMasami,MoriDaisuke,YasunamiMichio,SatoSeiji,MatsunagaHisashi,MaeTakao,KodamaKenji,KamijoTakehiko,KanekoYasuhiko,NakagawaraA
Products/Services Used Details Operation
Molecular Biology Reagents Full length CD133, Src, and GABARAP cDNAs were purchased from GenScript. Get A Quote

摘要

CD133 is a transmembranous protein that mainly localises to the plasma membrane in haematopoietic and neural stem cells as well as cancer stem cells. Although CD133 also localises to the cytoplasm, the mechanism of action and function of cytoplasmic CD133 currently remain unknown. We herein demonstrated that when Src family kinase activity is weak, CD133 interacts with HDAC6 and is transported to the pericentrosomal region after internalization and endosome formation via the dynein-based traffic system. Pericentrosomal CD133 is then recycled to the plasma membrane via recycling endosomes. At the pericentrosomal region, endosomal CD133 captures GABARAP, an initiator of autophagy, and inhibits GABARAP-m... More

关键词