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Imaging characteristics， tissue distribution， and spread of a novel oncolytic vaccinia virus carrying the human sodium iodide symporter.

PLoS ONE. 2012;

HaddadDana，ChenChun-Hao，CarlinSean，SilberhumerGerd，ChenNanhai G，ZhangQian，LongoValerie，CarpenterSusanne G，MittraArjun，CarsonJoshua，AuJoyce，GonenMithat，ZanzonicoPat B，SzalayAladar A，FongY

Products/Services Used	Details	Operation
Peptide Synthesis	For the VACV A27L antigen detection, slides were incubated with polyclonal antibody produced in rabbits against synthetic peptide AKKIDVQTGRRPYE (the C-terminal of A27L vaccinia protein) (custom made by GenScript Corporation, Piscataway, NJ)	Get A Quote

摘要

Oncolytic viruses show promise for treating cancer. However， to assess therapy and potential toxicity， a noninvasive imaging modality is needed. This study aims to determine the in vivo biodistribution， and imaging and timing characteristics of a vaccinia virus， GLV-1h153， encoding the human sodium iodide symporter (hNIS.