While influenza vaccination results in protective antibodies against primary infections， clearance of infection is primarily mediated through CD8+ T cells. Studying the CD8+ T cell response to influenza epitopes is crucial in understanding the disease associated morbidity and mortality especially in at risk populations such as the elderly. We compared the CD8+ T cell response to immunodominant and subdominant influenza epitopes in HLA-A2+ control， adult donors， aged 21-42， and in geriatric donors， aged 65 and older.
While influenza vaccination results in protective antibodies against primary infections， clearance of infection is primarily mediated through CD8+ T cells. Studying the CD8+ T cell response to influenza epitopes is crucial in understanding the disease associated morbidity and mortality especially in at risk populations such as the elderly. We compared the CD8+ T cell response to immunodominant and subdominant influenza epitopes in HLA-A2+ control， adult donors， aged 21-42， and in geriatric donors， aged 65 and older.
