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Stimulation of autophagy prevents amyloid-β peptide-induced neuritic degeneration in PC12 cells.

J. Alzheimers Dis.. 2014; 
YangYi,ChenSicong,ZhangJiafeng,LiChentan,SunYonghong,ZhangLihui,ZhengXiaox
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Custom Vector Construction … 966–986 bp). Each sequence flanked by BamH1 (5′‐end) and XhoI (3′‐end) sites was ligated into the lentiviral‐based short hairpin RNA (shRNA) vector (SD1259) (provided by GenScript Corporation, NJ, USA). As a control … Get A Quote

摘要

Autophagy is a lysosomal degradative process essential for neuronal homeostasis, whereas autophagic failure has been linked to accumulating neurodegenerative disorders. However, the precise role of autophagy in axonal and dendritic degeneration in Alzheimer's disease (AD) remains unclear. In this study, we aim to investigate the precise effect of autophagy in amyloid-β peptide (Aβ)25-35-mediated neurite degeneration. Aβ35-25, the non-neurotoxic reverse sequence analogue of Aβ25-35, was used as a negative control. Our results showed that Aβ25-35 dose-dependently suppressed PC12 proliferation and induced autophagy induction in neurites (axons and dendrites). A high proportion of autophagic structur... More

关键词

Alzheimer's disease,amyloid-β peptide,autophagy,neuritic degenera