| Products/Services Used | Details | Operation |
|---|---|---|
| Peptide Synthesis | … RR and RRIKA were synthesized by GenScript (Piscataway, NJ, USA) … Moreover, peptides reduced the release of TNFα and IL-6, which might benefit the healing of infected … significantly more effective in the treatment of MRSA skin lesions than treatment with either peptide alone … | Get A Quote |
The therapeutic efficacy of two novel short antimicrobial and anti-inflammatory peptides (RR and RRIKA) was evaluated in a mouse model of staphylococcal skin infection. RR (2%) and RRIKA (2%) significantly reduced the bacterial counts and the levels of proinflammatory cytokines， tumor necrosis factor (TNF)-α， and interleukin (IL)-6， in methicillin-resistant Staphylococcus aureus USA 300-0114 skin lesions. Furthermore， the combined therapy of RRIKA (1%) and lysostaphin (0.5%) had significantly higher antistaphylococcal and anti-inflammatory activity compared to monotherapy. This study supports the potential use of these peptides for topical treatment of methicillin-resistant Staphylococcus aureus skin i... More
