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Transportan-derived cell-penetrating peptide delivers siRNA to inhibit replication of influenza virus in vivo.

Drug Des Devel Ther. 2019; 
ZhangCuiling,RenWeigang,LiuQingxin,TanZhikai,LiJunwei,TongCh
Products/Services Used Details Operation
Gene Synthesis … dR) by linking TP and 9(dR). The sequence was GWTLNSAGYLLGKINLKALAALA KKILdRdRdRdRdRdRdRdRdR and synthesized by GenScript (Nanjing, People's Republic of China). Uncon-jugated siRNA against GFP gene … Get A Quote

摘要

In this study, we report on the development of an effective delivery system for siRNAs; a novel cell-penetrating peptide (CPP), T9(dR), obtained from transportan (TP), was used for in vivo and in vitro testing.

关键词

CPP,IV,NP,cell-penetrating peptide,influenza virus,inhibition,nucleoprotein,siRNA,transpo