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Four microRNAs Signature for Survival Prognosis in Colon Cancer using TCGA Data.

Sci Rep. 2016; 
XuJian,ZhaoJian,Zhan
Products/Services Used Details Operation
Custom Vector Construction Thermo Inc.). miRNAs sponge employed pLVX-shRNA2 vector which is purchased from Clonetech Inc. The complete sponge vector was constructed by Genscript Inc. 5-FU was from Selleck Inc. Statistics … " https://www.nature.com/articles/srep38306 Get A Quote

摘要

This study aims to develop microRNA expression signature for colon cancer survival prognosis based on the Cancer Genomic Common database. miRNAs levels between colon cancer and non-cancer tissues were screened by t-test (p < 0.05). Kaplan-Meier survival method was used to discriminate survival significant miRNAs, followed by miRNAs index accumulation to power the miRNAs-survival reliability. In the end, we test the selected miRNAs in HT126 colon cancer cells to validate its anti-cancer effect. The study identified a 84-miRNAs signature. Of the above 84 miRNAs, we got four miRNAs which were survival associated by using ROC curve method and Kaplan-Meier survival method (p < 0.001). The result showed... More

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