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Oxygen and glucose deprivation induces expression of Aim2, ASC, caspase-1 and NLRP3 in primary microglia and bone marrow-derived macrophages

Matters. 2016-06;

Jing Zhao, Joshua D Bernstock, Sixian Wang, Daniel Ye, Maria Spatz, Kory R Johnson, Xiaohong Li, Xinhui Li, John M Hallenbeck

Products/Services Used	Details	Operation
Molecular Biology Reagents	… observation. Methodslink. Reagents/kits. Rat macrophage colony stimulating factor (M-CSF) was purchased from GenScript (Piscataway, NJ). ELISA kits were obtained from R&D Systems (Minneapolis, MN). Lipopolysaccharide	Get A Quote

摘要

Microglia/macrophages are recognized as major contributors to brain inflammation after an ischemic stroke, which is metabolically characterized by oxygen and glucose deprivation (OGD). The impact of OGD on the expression of inflammasome-related proteins within microglia/macrophages remains unclear. Herein we report that OGD upregulates the expression of Aim2, ASC, caspase-1, NRLP3 and ultimately IL-1β in microglia and bone marrow-derived macrophages (BMDM).