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Robust HCV Genotype 3a Infectious Cell Culture System Permits Identification of Escape Variants With Resistance to Sofosbuvir.

Gastroenterology. 2016-12;

RamirezSantseharay，MikkelsenLotte S，GottweinJudith M，Bukh

Products/Services Used	Details	Operation
PCR Cloning and Subcloning	… 24. Cloning of HCV Genomes. The consensus NS3–NS5B DBN sequence was synthesized by GenScript (Piscataway, NJ) in 2 fragments that together with core-NS2 were subcloned into pS52 25 using standard techniques …	Get A Quote

摘要

Direct-acting antivirals (DAAs) effectively eradicate chronic hepatitis C virus (HCV) infection， although HCV genotype 3a is less responsive to these drugs. We aimed to develop genotype 3a infectious cultures and study the effects of inhibitors of NS5A and NS5B and resistance to sofosbuvir-the only nucleotide analog approved for treatment of chronic HCV infection.