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An influenza A virus (H7N9) anti-neuraminidase monoclonal antibody with prophylactic and therapeutic activity in vivo.

Antiviral Res.. 2016-11; 
WilsonJason R,GuoZhu,ReberAdrian,KamalRam P,MusicNedzad,GansebomShane,BaiYaohui,LevineMin,CarneyPaul,TzengWen-Pin,StevensJames,YorkI
Products/Services Used Details Operation
Custom Vector Construction … To generate a panel of recNA with a single mutation at solvent-exposed residues, a codon optimized cDNA encoding the ectodomain (residues 36-465) of the NA gene of Sh/2 was synthesized (GenScript USA Inc., NJ) and sub-cloned into pIEx-4 vector (EMD Millipore, MA … Get A Quote

摘要

Zoonotic A(H7N9) avian influenza viruses emerged in China in 2013 and continue to be a threat to human public health, having infected over 800 individuals with a mortality rate approaching 40%. Treatment options for people infected with A(H7N9) include the use of neuraminidase (NA) inhibitors. However, like other influenza viruses, A(H7N9) can become resistant to these drugs. The use of monoclonal antibodies is a rapidly developing strategy for controlling influenza virus infection. Here we generated a murine monoclonal antibody (3c10-3) directed against the NA of A(H7N9) and show that prophylactic systemic administration of 3c10-3 fully protected mice from lethal challenge with wild-type A/Anhui/1/2013 (... More

关键词

Antiviral,H7N9,Influenza,Monoclonal antibody,NA epitope,Neuramini