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Anti-inflammatory effects of the cannabidiol derivative dimethylheptyl-cannabidiol - studies in BV-2 microglia and encephalitogenic T cells.

J Basic Clin Physiol Pharmacol. 2016;

JuknatAna，KozelaEwa，KaushanskyNathali，MechoulamRaphael，Voge

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Peptide Synthesis	Lyophilized MOG35–55 peptide (MEVGWYRSPFSRVVHLYRNGK) purchased from GenScript (Piscataway, NJ, USA) was reconstituted in sterile phosphate buffered solution (PBS) and the stock solution stored in aliquots at −20 °C.	Get A Quote

摘要

Dimethylheptyl-cannabidiol (DMH-CBD)， a non-psychoactive， synthetic derivative of the phytocannabinoid cannabidiol (CBD)， has been reported to be anti-inflammatory in RAW macrophages. Here， we evaluated the effects of DMH-CBD at the transcriptional level in BV-2 microglial cells as well as on the proliferation of encephalitogenic T cells.