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MuSK is a BMP co-receptor that shapes BMP responses and calcium signaling in muscle cells.

Sci Signal. 2016-01; 
YilmazAtilgan,KattamuriChandramohan,OzdeslikRana N,SchmiedelCarolyn,MentzerSarah,SchorlChristoph,OanceaElena,ThompsonThomas B,FallonJust
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Custom Vector Construction Constructs encoding full-length and Ig3-lacking Fc-Fusion MuSK ectodomains were obtained from GenScript and were used at the indicated concentrations. Get A Quote

摘要

Bone morphogenetic proteins (BMPs) function in most tissues but have cell type-specific effects. Given the relatively small number of BMP receptors, this exquisite signaling specificity requires additional molecules to regulate this pathway's output. The receptor tyrosine kinase MuSK (muscle-specific kinase) is critical for neuromuscular junction formation and maintenance. Here, we show that MuSK also promotes BMP signaling in muscle cells. MuSK bound to BMP4 and related BMPs with low nanomolar affinity in vitro and to the type I BMP receptors ALK3 and ALK6 in a ligand-independent manner both in vitro and in cultured myotubes. High-affinity binding to BMPs required the third, alternatively spliced MuSK im... More

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