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Nuclear heparanase-1 activity suppresses melanoma progression via its DNA-binding affinity.

Oncogene. 2015; 
YangY,GorzelannyC,BauerA T,HalterN,KomljenovicD,BäuerleT,BorsigL,RoblekM,Schneide
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Custom Vector Construction Mouse B16F10 or ret transgenic melanoma cells transfected with control siRNA or siHPSE vectors (pRNAT-CMV3.1-Neo, GenScript USA Inc., Piscataway, NJ, USA) were inoculated Get A Quote

摘要

Heparanase-1 (HPSE) plays a pivotal role in structural remodeling of the ECM and the glycocalyx, thus conferring protumorigenic, proangiogenic and prometastatic properties to many cancer entities. In addition to its extracellular function, recent studies suggest an intracellular activity of HPSE with a largely unknown significance during tumor progression. Therefore, we investigated the relevance of the dual functions of HPSE to malignant melanoma in vitro, as well as in different mouse melanoma models based on the intradermal or intravenous injection of melanoma cells. Consistent with its extracellular action, an HPSE deficiency led to a reduced shedding of the glycocalyx accompanied by a reduced a... More

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