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Dual miRNA targeting restricts host range and attenuates neurovirulence of flaviviruses.

PLoS Pathog.. 2015-04; 
TsetsarkinKonstantin A,LiuGuangping,KenneyHeather,Bustos-ArriagaJose,HansonChristopher T,WhiteheadStephen S,PletnevAlexand
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Custom Vector Construction Intron sequence [nt. 857–989 in HaloTag CMV-neo vector pHTC (GenBank access # JF920305)] was synthesized by GenScript Inc. (Piscataway, NJ) and was introduced at positions 3922 and 8836 of DEN4 genome at AGCT sites. Get A Quote

摘要

Mosquito-borne flaviviruses are among the most significant arboviral pathogens worldwide. Vaccinations and mosquito population control programs remain the most reliable means for flavivirus disease prevention, and live attenuated viruses remain one of the most attractive flavivirus vaccine platforms. Some live attenuated viruses are capable of infecting principle mosquito vectors, as demonstrated in the laboratory, which in combination with their intrinsic genetic instability could potentially lead to a vaccine virus reversion back to wild-type in nature, followed by introduction and dissemination of potentially dangerous viral strains into new geographic locations. To mitigate this risk we developed a ... More

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