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Characterization of a human platelet antigen-1a-specific monoclonal antibody derived from a B cell from a woman alloimmunized in pregnancy.

J. Immunol.. 2015-06; 
EksteenMariana,TillerHeidi,AverinaMaria,HeideGøril,KjaerMette,GhevaertCedric,MichaelsenTerje E,IhleØistein,HusebekkAnne,SkogenBjørn,StugeT
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Custom Vector Construction H and L chain V region genes coding for Ab 26.4 were synthesized by GenScript (Piscataway, NJ) optimizing the codon usage in the synthesized genes for high-level Ab expression in human cells...Each of the 26.4 genes was supplied in the pUC57 vector (GenScript). Get A Quote

摘要

Human platelet Ag (HPA)-1a, located on integrin β3, is the main target for alloantibodies responsible for fetal and neonatal alloimmune thrombocytopenia (FNAIT) in the white population. There are ongoing efforts to develop an Ab prophylaxis and therapy to prevent or treat FNAIT. In this study, an mAb specific for HPA-1a, named 26.4, was derived from an immortalized B cell from an alloimmunized woman who had an infant affected by FNAIT. It is the only HPA-1a-specific human mAb with naturally paired H and L chains. Specific binding of mAb 26.4, both native and recombinant forms, to platelets and to purified integrins αIIbβ3 (from platelets) and αVβ3 (from trophoblasts) from HPA-1a(+) donors was... More

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