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Chronic inflammation up-regulates P-gp in peripheral mononuclear blood cells via the STAT3/Nf-κb pathway in 2,4,6-trinitrobenzene sulfonic acid-induced colitis mice.

Sci Rep. 2015; 
LiuJiali,ZhouFang,ChenQianying,KangAn,LuMeng,LiuWenyue,ZangXiaojie,WangGuangji,ZhangJin
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Custom Vector Construction … Cell Culture The human T lymphoblast CCRF-CEM cell line and the human monocyte THP-1 cell line were purchased from American Type Culture Collection The CCRF-CEM MDR1 cell line was constructed by GenScript Co, Ltd … Get A Quote

摘要

Patients with inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, often suffer drug intolerance. This resistance can be divided into intrinsic resistance and acquired resistance. Although there is agreement on acquired resistance, studies regarding intrinsic resistance have demonstrated inconsistencies, especially for Crohn's disease. For this reason, an animal model of Crohn's disease was induced with 2,4,6-trinitrobenzene sulfonic acid solution (TNBS), and intrinsic resistance was analyzed by measuring the function and expression of P-glycoprotein (P-gp) in peripheral mononuclear blood cells (PMBC), followed by mechanistic studies. The results revealed reduced rete... More

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