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Nephroprotective role of dipyridamole in diabetic nephropathy: Effect on inflammation and apoptosis.

Life Sci.. 2015;

ElsherbinyNehal M，Al-GayyarMohammed M H，Abd El GalilKhal

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Molecular Biology Reagents	… Caspase-3, caspase-8 and caspase-9 enzyme activity assay was measured colorimetrically using commercially available kit (GenScript, Piscataway, NJ, USA) following the manufacture procedure 28 Cells culture 281 Human mesangial cells …	Get A Quote

摘要

Inflammation plays significant roles in developing diabetic nephropathy (DN). Adenosine， natural purine nucleoside， acts as potent endogenous anti-inflammatory agent. Extracellular adenosine usually disappears quickly due to rapid uptake into adjacent cells. In this regard; we investigated putative reno-protective effects of dipyridamole， nucleoside transport inhibitor， by exploring its anti-inflammatory mechanisms in-vivo and in-vitro.