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Rapamycin Improves Mortality Following Intestinal Ischemia-Reperfusion via the Inhibition of Remote Lung Inflammation in Mice.

Digestion. 2015;

IidaTakaya，TakagiTomohisa，KatadaKazuhiro，MizushimaKatsura，FukudaWataru，KamadaKazuhiro，UchiyamaKazuhiko，HandaOsamu，IchikawaHiroshi，NaitoYuji，ItohYos

Products/Services Used	Details	Operation
Molecular Biology Reagents	… Serum Endotoxin Levels The chromogenic Limulus Amebocyte Lysate Endotoxin Assay kit (GenScript USA Inc, Piscataway, NJ, USA) was used to measure serum endotoxin levels 12 h after the induction of intestinal ischemia …	Get A Quote

摘要

Acute-phase intestinal ischemia-reperfusion (I-R) injury can result in multiple organ failure， which may sometimes be fatal. However， no reliable treatment for this clinical state is available. Rapamycin has been reported to protect heart， brain and kidney against I-R injury. The aim of this study was to examine whether rapamycin could protect mice against I-R-induced intestinal and remote organ injury.