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PTPROt maintains T cell immunity in the microenvironment of hepatocellular carcinoma.

J Mol Cell Biol. 2015; 
HouJiajie,DengLei,ZhuoHan,LinZhe,ChenYun,JiangRunqiu,ChenDianyu,ZhangXudong,HuangXingxu,SunBeic
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Custom Vector Construction … culture Mouse PTPROt (NM_001164402) exons were synthesized by GenScript Inc (China), and subcloned into retroviral vector pMXs-GFP … Promoter mutant containing point mutations at HRE (-22-- 14 bp) was synthesized by GenScript Inc (China) … Get A Quote

摘要

Intratumoral T cells play a central role in anti-tumor immunity, and the balance between T effector cells (Teff) and regulatory T cells (Treg) affects the prognosis of cancer patients. However, educated by tumor microenvironment, T cells frequently fail in their responsibility. In this study, we aimed to investigate the role of truncated isoform of protein tyrosine phosphatase receptor-type O (PTPROt) in T cell-mediated anti-tumor immunity. We recruited 70 hepatocellular carcinoma (HCC) patients and 30 healthy volunteers for clinical investigation, and analyzed cellular tumor immunity by using ptpro(-/-) C57BL/6 mice and NOD/SCID mice. PTPROt expression was significantly downregulated in human HCC-inf... More

关键词

PTPROt,Teff,Treg,hepatocellular carci