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Structure-based Design Targeted at LOX-1, a Receptor for Oxidized Low-Density Lipoprotein.

Sci Rep. 2015; 
ThakkarShraddha,WangXianwei,KhaidakovMagomed,DaiYao,GokulanKuppan,MehtaJawahar L,VarugheseKottay
Products/Services Used Details Operation
Custom Vector Construction … disulfide isomerase The genes were custom synthesized by Genscript (Piscataway, NJ) using gene map described in Park el al 12 It encodes … for DsbC The gene was incorporated into a pET15b vectors by Genscript The vectors … Get A Quote

摘要

Atherosclerosis related cardiovascular diseases continue to be the primary cause of mortality in developed countries. The elevated level of low density lipoprotein (LDL) is generally considered to be the driver of atherosclerosis, but recent years have seen a shift in this perception in that the vascular plaque buildup is mainly caused by oxidized LDL (ox-LDL) rather than native-LDL. The scavenger receptor LOX-1 found in endothelial cells binds and internalizes ox-LDL which leads to the initiation of plaque formation in arteries. Using virtual screening techniques, we identified a few potential small molecule inhibitors of LOX-1 and tested their inhibitory potential using differential scanning fluorimetry a... More

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