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Modulation of tumor cell migration, invasion and cell-matrix adhesion by human monopolar spindle-one-binder 2.

Oncol. Rep.. 2015-05; 
WuWenjuan,ZhangXizhi,QinHaonan,PengWanxin,XueQingyu,LvHouning,ZhangHua,QiuYumei,ChengHaichao,ZhangYu,YuZhiyong,ShenWe
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Custom Vector Construction … Corporation To construct the lentiviral vectors expressing siRNA targeting hMOB2, four different siRNA targeting sequences directed against hMOB2 were selected under the guide of siRNA designing software provided by GenScript Get A Quote

摘要

Human monopolar spindle-one-binder 2 (hMOB2) is a member of the hMOB family of proteins, and it has been reported to regulate the nuclear-Dbf2-related kinase (NDR) activation. However, the function of hMOB2 expression in tumor cell adhesion and motility has not been addressed. Herein, the lentiviral-mediated overexpression and the knockdown of hMOB2 in HepG2 and SMMC-7721 cells was established. It was demonstrated that overexpression of hMOB2 significantly reduced the cell motility and enhanced the cell-matrix adhesion, while the hMOB2 knockdown decreased not only the cell motility, but also the cell-matrix adhesion. Immunofluorescence results showed that both hMOB2 overexpression and knockdown altere... More

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