至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

MeCP2 controls hippocampal brain-derived neurotrophic factor expression via homeostatic interactions with microRNA‑132 in rats with depression.

Mol Med Rep. 2015; 
SuMeilei,HongJun,ZhaoYongzhi,LiuShuai,XueX
Products/Services Used Details Operation
Custom Vector Construction … For MeCP2 knockdown, a 70 nt short hairpin RNA (shRNA) was designed by GenScript Co, Ltd (Nanjing, China) and pRNA-U61/Neo/CTL (cat no … The shRNA was cloned into the pRNAT-U62/Lenti expression vector by GenScript Co, Ltd … Get A Quote

摘要

Major depressive disorder (MDD) is a considerable public health concern, which affects patients worldwide. MDD is associated with psychosocial impairment, poor quality of life, and significant disability, morbidity and mortality. Stress is a major factor in depression, which impairs the structural and functional plasticity of the hippocampus. Previous studies have demonstrated that chronic unpredictable mild stress is able to downregulate the expression of brain‑derived neurotrophic factor (BDNF) and methyl‑CpG‑binding protein 2 (MeCP2), and alter the expression levels of certain microRNAs (miR). The aim of the present study was to investigate the regulatory association between BDNF, MeCP2 a... More

关键词