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Vielanin P enhances the cytotoxicity of doxorubicin via the inhibition of PI3K/Nrf2-stimulated MRP1 expression in MCF-7 and K562 DOX-resistant cell lines.

Phytomedicine. 2019; 
GaoHong-Liang，XiaYuan-Zheng，ZhangYa-Long，YangLei，KongLin
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Plasmid DNA Preparation … The MRP1 plasmid was obtained from Genscript (Nanjing, China). Cell lines and cell culture … Cell viability assays. Cell proliferation was determined by using the MTT and CCK-8 assay as described previously (Kukhetpitakwong et al., 2006). Apoptosis assay … Get A Quote

摘要

Cancer cells that are resistant to structurally and mechanically unrelated anticancer drugs are said to have multidrug resistance (MDR). The overexpression of the ATP-binding cassette (ABC) transporter is one of the most important mechanisms of MDR. Vielanin P (VP)， a dimeric guaiane from the leaves of Xylopia vielana， has the potential to reverse multidrug resistance.

关键词

MRP1，Meroterpenoid，Multidrug resistance，PI3K，Vielan
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