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Chinese medicine Jinlida granules improve high-fat-diet induced metabolic disorders via activation of brown adipose tissue in mice.

Biomed. Pharmacother.. 2019; 
ZhangHui,HaoYuanyuan,WeiCong,YaoBing,LiuShen,ZhouHongru,HuangDan,ZhangChuanhai,WuYi
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Gene Synthesis … gene cyclophilin A and analyzed using the 2 -ΔΔ Ct method. The primer sequences used in the study were listed in Supplementary Table S2. 2.7. Western blot analysis. The protein samples were collected, separated on 12% SurePAGE gels (GenScript, China) and afterwards … Get A Quote

摘要

Activation of brown adipose tissue (BAT) thermogenesis could contribute to energy expenditure, which is critical for the treatment of obesity and type 2 diabetes mellitus (T2DM). In the present study, we aimed to systematically investigate whether traditional Chinese medication Jinlida (JLD) granules could improve metabolic disorders and activate BAT thermogenesis in C57BL/6 J mice fed with a high-fat diet (HFD).

关键词

Brown adipose tissue,Fatty acid oxidative,Jinlida granules,Mitochondrial biogenesis,Type 2 diabetes mell