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Streamlined SMFA and mosquito dark-feeding regime significantly improve malaria transmission-blocking assay robustness and sensitivity.

Malar. J.. 2019;

HabtewoldTibebu，TapanelliSofia，MastersEllen K G，HoermannAstrid，WindbichlerNikolai，ChristophidesGeor

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Gene Synthesis	The development of malaria transmission-blocking strategies including the generation of malaria refractory mosquitoes to replace the wild populations through means of gene drives hold great promise. The standard membrane feeding assay (SMFA) that involves mosquito feeding …AMPs were synthesized by GenScript USA Inc. Before mosquito infection, AMPs were dissolved in distilled PBS and warmed up at 37 °C on a heat block.	Get A Quote

摘要

The development of malaria transmission-blocking strategies including the generation of malaria refractory mosquitoes to replace the wild populations through means of gene drives hold great promise. The standard membrane feeding assay (SMFA) that involves mosquito feeding on parasitized blood through an artificial membrane system is a vital tool for evaluating the efficacy of transmission-blocking interventions. However， despite the availability of several published protocols， the SMFA remains highly variable and broadly insensitive.