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Elevated IL-16 expression is associated with development of immune dysfunction in children with autism.

Psychopharmacology (Berl.). 2019; 
AhmadSheikh F,AnsariMushtaq A,NadeemAhmed,BakheetSaleh A,Al-AyadhiLaila Y,AttiaSab
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Gene Synthesis … The following primers were used (Genscript, Piscataway, USA); GAPDH forward: 5′-GCTCCCTCTTTCTTTGCAGC-3′; and reverse: 5′-GTTGTCATGGATGACCTTGGC- 3′. IL-16 forward: 5′-TCCTGATCTAGCACTGGCCT-3′; and reverse: 5 … Get A Quote

摘要

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in communication skills and social behaviors. Several studies have suggested that neuroimmune dysfunction plays a significant role in the pathogenesis of ASD; however, its exact etiology is unknown. Interleukin-16 (IL-16), a chemoattractant, is associated with various inflammatory processes. However, its role in children with ASD is unclear. This study aimed to investigate whether IL-16 expression is associated with immune dysfunction in children with ASD. We examined IL-16 expression in CD4, CD8, CD14, CCR3, and CXCR7 cells in typically developing (TD) controls and children with ASD using flow cytometry... More

关键词

Autism spectrum disorder,Cytokines,Interleukin-16,Peripheral blood mononuclear cells,Typically developing cont