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Sex influences DNA methylation and gene expression in human skeletal muscle myoblasts and myotubes.

Stem Cell Res Ther. 2019;

DavegårdhCajsa，Hall WedinElin，BroholmChrista，HenriksenTora Ida，PedersenMaria，PedersenBente Klarlund，ScheeleCamilla，LingCharl

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Gene Synthesis	Sex differences are known to impact muscle phenotypes, metabolism, and disease risk. Skeletal muscle stem cells (satellite cells) are important for muscle repair and to maintain functional skeletal muscle. Here we studied, for the first time, effects of sex on DNA methylation and gene …RPS4X were cloned into a CpG-free luciferase vector (pCpGL-basic) [27] and amplified by GenScript (GenScript USA Inc., Piscataway, NJ, USA...	Get A Quote

摘要

Sex differences are known to impact muscle phenotypes， metabolism， and disease risk. Skeletal muscle stem cells (satellite cells) are important for muscle repair and to maintain functional skeletal muscle. Here we studied， for the first time， effects of sex on DNA methylation and gene expression in primary human myoblasts (activated satellite cells) before and after differentiation into myotubes.