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Curdione inhibits thrombin-induced platelet aggregation via regulating the AMP-activated protein kinase-vinculin/talin-integrin αIIbβ3 sign pathway.

Phytomedicine. 2019; 
FangHui,GaoBeibei,ZhaoYingli,FangXing,BianMaohong,Xia
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Gene Synthesis … The obtained samples were analyzed by western blot assay. For western blot experiments, equivalent amounts of protein were separated by 12% SDS-PAGE and transferred to a 0.45 μM PVDF membrane (Millipore, USA) … All primers were designed by GenScript in China … Get A Quote

摘要

Curdione, a sesquiterpene compound isolated from the essential oil of Curcuma aromatica Salisb. inhibits platelet aggregation, suggesting its significant anticoagulant and antithrombotic effects. However, the mechanisms have not been fully elucidated.

关键词

AMPK,Curdione,Platelet aggregation,Talin,Vinc