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Simultaneous Deletion of the 9GL and UK Genes from the African Swine Fever Virus Georgia 2007 Isolate Offers Increased Safety and Protection against Homologous Challenge.

ournal of Virology, 91(1).. 2016-12; 
Vivian O’Donnell,, Guillermo R. Risatti , Lauren G. Holinka , Peter Krug , Jolene Carlson, , Lauro Velazquez-Salinas , Paul A. Azzinaro , Douglas P. Gladue , and Manuel V. Borca,* Agricultural Research Service, U.S. Department of Agriculture, Plum Island Animal Disease Center, Greenport, NY , USA. Department of Pathobiology and Veterinary Science, CANR, University of Connecticut, Storrs, CT 0, USA. 0 Biosecurity Research Institute and Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 0.
Products/Services Used Details Operation
Custom Vector Construction Recombinant transfer vector p72GUSΔ9GL 129 was obtained by DNA synthesis (GenScript, Piscataway, NJ, USA) This construction created a 255-nucleotide deletion in the UK ORF on November 1, 2016 by UNIV OF CALIF SAN DIEGO http://jvi.asm.org/ Downloaded from 8 138 (amino acid residues 1 to 85) (see Fig. 1). Recombinant transfer vector p72mCheryΔUK was obtained 139 by DNA synthesis (GenScript, Piscataway, NJ, USA). Get A Quote

摘要

African swine fever virus (ASFV) is the etiological agent of a contagious and often lethal viral 20 disease of domestic pigs that has significant economic consequences for the swine industry. The control 21 of African Swine Fever (ASF) has been hampered by the unavailability of vaccines. Successful 22 experimental vaccines have been derived from naturally occurring, cell culture-adapted, or genetically 23 modified live attenuated ASFV. Recombinant viruses harboring engineered deletions of specific 24 virulence-associated genes induce solid protection against challenge with parental viruses. Deletion of 25 the 9GL (B119L) gene in highly virulent ASFVs Malawi Lil-20/1 (Mal) and Pretoriuskop/96/4 (Δ9GL 26 viruses... More

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