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Molluscum contagiosum virus protein MC005 inhibits NF-κB activation by targeting NEMO-regulated IκB kinase activation

The American Society for Biochemistry and Molecular Biology, Inc. 2017; 
Hisao Tsukamoto, *, I-Shan Chen, , Yoshihiro Kubo, and Yuji Furutani
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Custom Vector Construction was synthesized by GenScript, Piscataway, NJ. The cDNAs of WT and mutants of Platynereis c-opsin were inserted into the EcoRI/NotI site in a mammalian expression vector pMT using in-Fusion HD (TAKARA, Kusatsu, Japan). Get A Quote

摘要

Ciliary opsins were classically thought to function only in vertebrates for vision, but they have been recently identified also in invertebrates for non-visual photoreception. Larvae of the annelid Platynereis dumerilii are used as a zooplankton model, and this zooplankton species possesses a "vertebrate-type" ciliary opsin (named c-opsin) in the brain. Platynereis c -opsin is suggested to relay light signals to melatonin production and circadian behaviors. Thus, the spectral and biochemical characteristics of this c-opsin would be directly related to non-visual photoreception in this zooplankton model. Here, we demonstrate that the c-opsin can sense UV to activate intracellular signaling cascades, and tha... More

关键词

: rhodopsin, molecular evolution, brain, photobiology, G protein-coupled receptor, ultraviolet-visible spectroscopy, opsin, UV (UV-A) reception, zooplankton.