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miR-490-3p modulates the progression of prostate cancer through regulating histone deacetylase 2.

Eur Rev Med Pharmacol Sci. 2019-01;

FanH, Zhan

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Gene Synthesis	… The construct containing the open reading frame sequence of HDAC2 (pcDNA3.1-HDAC2) and empty vector (pcDNA3.1) were built by GenScript (Nanjing, Jiangsu, China). 1×105 PCa cells were seeded in 6-well plates and cultured to about 60% confluence …	Get A Quote

摘要

microRNAs (miRNAs) were regarded as critical participators for human cancers progression including prostate cancer (PCa) and have the potential to be used as treatment targets for cancers. Herein， we validated a tumor-suppressive miRNA， miR-490-3p， which may suppress PCa progression. Histone deacetylase 2 (HDAC2) is a protein that aberrantly expressed in several cancers. However， the role of HDAC2 in the progression of PCa has not been fully elucidated.