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MicroRNA-128 confers protection against cardiac microvascular endothelial cell injury in coronary heart disease via negative regulation of IRS1.

J. Cell. Physiol.. 2019-01;

YanPing, SunChen, MaJiale, JinZhigang, GuoRui, Yan

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Gene Synthesis	… The mutant sequences of binding sites were designed. Next, the target sequence fragments were synthesized by the Genscript Corp. (Nanjing, Jiangsu, China) … The total RNA in cells and tissues was extracted by a TRIzol method (Takara Biotechnology Ltd., Dalian, China) …	Get A Quote

摘要

Cardiac microvascular endothelial cells (CMECs) play a critical role in the physiological regulation of coronary blood flow and its dysfunction is associated with myocardium ischemic injury. This study was performed to clarify the effect of microRNA-128 (miR-128) on the CMEC injury in coronary heart disease (CHD) by binding to insulin receptor substrate 1 (IRS1).