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Adipocyte-derived stem cell-based gene therapy upon adipogenic differentiation on microcarriers attenuates type 1 diabetes in mice.

Stem Cell Res Ther. 2019-01;

FangQing, ZhaiMin, WuShan, HuXiaogen, HuaZhan, SunHuizhuo, GuoJing, ZhangWenjian, Wan

Products/Services Used	Details	Operation
Gene Synthesis	… of the transcription starting site and the enhancer sequence from ? 5.4 to ? 4.9 kb of AP2 gene was synthesized according to the literature [25] and replaced the EF1 promoter (GenScript, Nanjing, China) to generate pcDH-AP2-INS-IRES-puro and pcDH-AP2-INS-IRES-EGFP …	Get A Quote

摘要

Insulin replenishment is critical for patients with type 1 diabetes; however， current treatments such as pancreatic islet transplantation and insulin injection are not ideal. In addition to stem cell or gene therapy alone， stem cell combined with gene therapy may provide a new route for insulin replenishment， which could avoid an autoimmune reaction against differentiated β cells or systematic viral vector injection.