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Copy number variation of PR-39 cathelicidin, and identification of PR-35, a natural variant of PR-39 with reduced mammalian cytotoxicity.

Gene. 2019-04; 
JeonHyoim, LeMinh Thong, AhnByeongyong, ChoHye-Sun, LeVan Chanh Quy, YumJoori, HongKwonho, KimJin-Hoi, SongHyuk, ParkCha
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Gene Synthesis … HPLC high performance liquid chromatography. MIC Mininal Inhibitory Concentration. NCBI National Center for Biotechnology Information. PR … synthesis and purified by high performance liquid chromatography using a commercial service (GenScript, Piscataway Township, NJ … Get A Quote

摘要

Proline-arginine-rich (PR)-39 is neutrophil antimicrobial peptide that has potent antimicrobial activity against a broad spectrum of microorganisms, including bacteria, fungi, and some enveloped viruses as a part of the innate immune system. We analyzed the nucleotide sequence variations of PR-39 exon 4, which is the mature peptide region responsible for antimicrobial activity, from 48 pigs of six breeds using sequence-based typing. The analysis identified four alleles including allele PR-35 with a 12-bp deletion near the N-terminus. Interestingly, 16.7% of individuals showed the presence of three alleles per individual, but only in the Berkshire and Duroc breeds. We further analyzed the genetic d... More

关键词

Antimicrobial activity,Antimicrobial peptide,Cathelicidin,Cytotoxicity,Sus sc