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rs187960998 polymorphism in miR-211 prevents development of human colon cancer by deregulation of 3'UTR in CHD5.

Onco Targets Ther. 2019-01;

ZhuLimei, WangRan, ZhangLi, ZuoChunlei, ZhangRui, ZhaoSha

Products/Services Used	Details	Operation
Gene Synthesis	… Promega, Madison, WI, USA). The construction containing both CC and TT genotype of miR-211 was also synthesized and cloned into a pSilence 2.1-U6 plasmid in Genscript Co. (Nanjing, China). Dual-luciferase reporter assay …	Get A Quote

摘要

Previous research indicated that overexpression of miRNA-211 could promote colorectal cancer cell growth by targeting tumor suppressive gene Chromodomain-helicase-DNA-binding protein 5 (CHD5) in human colon cancer (CC). Moreover， the function of the single-nucleotide polymorphism (SNP) located in the mature region of miR-211 has not been investigated. In this study， we found that SNP of rs187960998 in miR-211 was involved in the occurrence of CC by acting as a tumor suppressor by mal-regulation of its target gene .