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Proteomic analysis of cell cycle arrest and differentiation induction caused by ATPR， a derivative of all-trans retinoic acid， in human gastric cancer SGC-7901 cells.

Proteomics Clin Appl. 2017-07; 
XiaQuan, ZhaoYingli, WangJiali, QiaoWenhao, ZhangDongling, YinHao, XuDujuan, ChenF
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Gene Synthesis … The primers were designed by GenScript in China and the sequence information is shown in (Supporting informa- tion S1). The cDNA was synthesized from 100ng total RNA by FastQuant RT Super Mix (TIANGEN, China) as described in the manufacturer's instructions … Get A Quote

摘要

4-amino-2-trifluoromethyl-phenyl retinate (ATPR) was reported to potentially inhibit proliferation and induce differentiation activity in some tumor cells. In this study， a proteomics approach was used to investigate the possible mechanism by screening the differentially expressed protein profiles of SGC-7901 cells before and after ATPR-treatment in vitro.

关键词

ATPR，Cell cycle arrest and differentiation，PI3K-AKT-FOXO-P27kip1 pathway，Proteomics analysis，SGC-7901 c
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