Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which glia are central mediators of motor neuron (MN) death. Since multiple cell types are involved in disease pathogenesis， the objective of this study was to determine the benefit of co-targeting independent pathogenic mechanisms in a familial ALS mouse model.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which glia are central mediators of motor neuron (MN) death. Since multiple cell types are involved in disease pathogenesis， the objective of this study was to determine the benefit of co-targeting independent pathogenic mechanisms in a familial ALS mouse model.
