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Both Systemic and Intra-articular Immunization with Citrullinated Peptides Are Needed to Induce Arthritis in the Macaque.

Front Immunol. 2017-01; 
BitounSamuel, RoquesPierre, LarcherThibaut, NocturneGaétane, SergueraChe, ChrétienPascale, SerreGuy, GrandRoger Le, MarietteXa
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Gene Synthesis … 59-71 (Vim59), vimentin 66-78 (Vim66) fibrinogen alpha chain 79-91 (Fg79), and aggrecan 89-103 (Agg89) (Table S4 in Supplementary Material) were synthesized in native or citrullinated form, the arginyl substituted by citrullyl residues (Genscript, Piscataway, NJ, USA) … Get A Quote

摘要

Anti-citrullinated peptides antibodies (ACPAs) have high specificity for the diagnosis of rheumatoid arthritis (RA)， but their role in the pathophysiology is not fully established. The main genetic risk factor for RA， the shared epitope in major histocompatibility complex class II， is associated with ACPAs. Among certain non-human primates， 8% carry the shared epitope called H6 haplotype， and being similar to humans， are ideal candidates to study the role of ACPAs in RA. The goal of this study was to develop a macaque model of RA based on immunization against citrullinated peptides to generate an ACPA-mediated model of arthritis.

关键词

ACPA，citrulline，macaque，neutrophils，rheumatoid arthritis，shared epi
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