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Measurement of Lipoprotein-Associated Phospholipase A2 by Use of 3 Different Methods: Exploration of Discordance between ELISA and Activity Assays.

Clin. Chem.. 2018-04; 
TopbasCelalettin,SwickAlan,RazaviMorteza,AndersonN Leigh,PearsonTerry W,Bystrom
Products/Services Used Details Operation
Monoclonal Antibody Services … Recombinant native and15N-labeled Lp-PLA2 was produced by Genscript. Bovine pancreatic trypsin (Cat. No … Get A Quote

摘要

Lipoprotein-associated phospholipase A2 (Lp-PLA), an enzyme associated with inflammation, is used as a biomarker for cardiovascular disease risk. Both the concentration and activity of Lp-PLA have been shown to be clinically relevant. However, there is a discordance between the serum concentration of Lp-PLA measured by the standard ELISA-based immunoassays and the activity of this enzyme, leading to substantial discordance in risk categorization depending on assay format.

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