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Fusion proteins of flagellin and the major birch pollen allergen Bet v 1 show enhanced immunogenicity， reduced allergenicity， and intrinsic adjuvanticity.

J. Allergy Clin. Immunol.. 2018-01;

KitzmüllerClaudia，KalserJulia，MutschlechnerSonja，HauserMichael，ZlabingerGerhard J，FerreiraFatima，BohleBar

Products/Services Used	Details	Operation
Gene Synthesis	… a size of 49 kDa. For better expression, harmonized versions of Bet v 1–NtCFlg and NtCFlg–Bet v 1 were synthesized by Genscript (Piscataway, NJ) and cloned into the NcoI/XhoI site of pHis parallel 2. NtCFlg, Bet v 1–NtCFlg …	Get A Quote

摘要

Recombinant fusion proteins of flagellin and antigens have been demonstrated to induce strong innate and adaptive immune responses. Such fusion proteins can enhance the efficacy of allergen-specific immunotherapy.