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Mesenchymal stem cell transplantation improves chronic colitis-associated complications through inhibiting the activity of toll-like receptor-4 in mice.

BMC Gastroenterol. 2018-08;

NiuGuo Chao，LiuLei，ZhengLibo，ZhangHong，ShihDavid Q，ZhangXia

Products/Services Used	Details	Operation
Proteins, Expression, Isolation and Analysis	… Endotoxin assay. A limulus amebocyte lysate (LAL-Test, GenScript, USA) was used, according to the manufacturer's instructions. Disease activity index (DAI), and macroscopic and histopathological analyses of colonic injury …	Get A Quote

摘要

A variety of extra-intestinal manifestations (EIMs)， including hepatobiliary complications， are associated with inflammatory bowel disease (IBD). Mesenchymal stem cells (MSCs) have been shown to play a potential role in the therapy of IBD. This study was designed to investigate the effect and mechanism of MSCs on chronic colitis-associated hepatobiliary complications using mouse chronic colitis models induced by dextran sulfate sodium (DSS).