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Synthetic hydrogels formed by thiol-ene crosslinking of vinyl sulfone-functional poly(methyl vinyl ether-alt-maleic acid) with α,ω-dithio-polyethyleneglycol.

Soft Matter. 2018-11; 
StewartS A,CoulsonM B,ZhouC,BurkeN A D,StöverH
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Proteins, Expression, Isolation and Analysis … Di-tert-butyl dicarbonate was purchased from Fluka Analytical. Triethylamine (TEA) was purchased from EMD Performance Chemicals. Arg-Gly-Asp-Cys was purchased from GenScript. Formic acid (≥98%) was purchased from EM Science … Get A Quote

摘要

Polymer hydrogels formed by rapid thiol-ene coupling of macromolecular gel formers can offer access to versatile new matrices. This paper describes the efficient synthesis of cysteamine vinyl sulfone (CVS) trifluoroacetate, and its incorporation into poly(methyl vinyl ether-alt-maleic anhydride) (PMMAn) to form a series of CVS-functionalized poly(methyl vinyl ether-alt-maleic acid) polymers (PMM-CVS) containing 10 to 30 mol% pendant vinyl sulfone groups. Aqueous mixtures of these PMM-CVS and a dithiol crosslinker, α,ω-dithio-polyethyleneglycol (HS-PEG-SH, M = 1 kDa), gelled through crosslinking by Michael addition within seconds to minutes, depending on pH, degree of functionalization, and pol... More

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