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Immunopathogenic And Antibacterial Effects Of H3N2 Influenza A Virus Pb1-F2 Map To Amino Acid Residues 62, 75, 79, And 82.

J Virol.. 2011-12;  85(23):12324-12333
Irina V. Alymova, Amanda M. Green, Nicholas van de Velde, Julie L. McAuley, Kelli L. Boyd, Hazem E. Ghoneim, and Jonathan A. McCullers. Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-2794, USA.
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摘要

The influenza A virus protein PB1-F2 has been linked to the pathogenesis of both primary viral and secondary bacterial infections. H3N2 viruses have historically expressed full-length PB1-F2 proteins with either proinflammatory (e.g., from influenza A/Hong Kong/1/1968 virus) or noninflammatory (e.g., from influenza A/Wuhan/359/1995 virus) properties. Using synthetic peptides derived from the active C-terminal portion of the PB1-F2 protein from those two viruses, we mapped the proinflammatory domain to amino acid residues L62, R75, R79, and L82 and then determined the role of that domain in H3N2 influenza virus pathogenicity. PB1-F2-derived peptides containing that proinflammatory motif caused significant morbid... More

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