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Mast cells partially contribute to mucosal adjuvanticity of surfactin in mice.

Immun Inflamm Dis. 2018-03;

YoshinoNaoto，TakeshitaRyosuke，KawamuraHanae，SasakiYutaka，KagabuMasahiro，SugiyamaToru，MurakiYasushi，SatoShige

Products/Services Used	Details	Operation
Proteins, Expression, Isolation and Analysis	… (Osaka, Japan). Endotoxin concentration was determined to be <0.1 endotoxin units (EU)/mg of SF, using a Chromogenic Limulus Amebocyte Lysate Endotoxin Assay Kit (GenScript, Piscataway, NJ, USA). Immunization of mice …	Get A Quote

摘要

Surfactin (SF) is a cyclic lipopeptide that has potent mucosal adjuvant properties. However， immunological mechanisms of SF adjuvant action have not yet been elucidated. As some cyclic lipopeptides， such as polymyxin， can stimulate histamine release from mast cells， we hypothesized that mast cell activation is critical for SF adjuvanticity.