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Production and Evaluation of Virus-Like Particles Displaying Immunogenic Epitopes of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV).

Int J Mol Sci.. 2015-04; 
Murthy AM, Ni Y, Meng X, Zhang C. Department of Biological Systems Engineering, Virginia Tech, Blacksburg, VA 24061, USA
Products/Services Used Details Operation
Custom Vector Construction ...of hepatitis B virus core protein. The nucleotide sequence of 585 bp, coding for this construct, was codon optimized using Optimum Gene&trade; by <b>genscript</b> Corporation (Piscataway, NJ, USA). The...instructions (<b>genscript</b> Corporation, Piscataway, NJ, USA). Acknowledgments... Get A Quote

摘要

Porcine reproductive and respiratory syndrome (PRRS) is the most significant infectious disease currently affecting the swine industry worldwide. Several inactivated and modified live vaccines (MLV) have been developed to curb PRRSV infections. However, the efficacy and safety of these vaccines are unsatisfactory, and hence, there is a strong demand for the development of new PRRS universal vaccines. Virus-like particle (VLP)-based vaccines are gaining increasing acceptance compared to subunit vaccines, as they present the antigens in a more veritable conformation and are readily recognized by the immune system. Hepatitis B virus core antigen (HBcAg) has been successfully used as a carrier for more than 100 vir... More

关键词

porcine reproductive and respiratory syndrome virus; PRRSV; vaccine; VLP; inclusion bodies