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Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif

Authors: Wuyang Shi , Shibo Sun , Haowen Liu , Yao Meng , Kangshuai Ren , Guoying Wang , Minghui Liu , Jiaqi Wu , Yue Zhang , Huang Huang , Meiyun Shi , Weiping Xu , Qiang Ma , Bingbing Sun , Jianqiang Xu

Journal: Redox biology

Doi: 10.1016/j.redox.2024.103050

Products & Services: Proteins, Expression, Isolation and Analysis

Engineering minimal tissue inhibitors of metalloproteinase targeting MMPs via gene shuffling and yeast surface display

Authors: Arman Hosseini, Sachin Kumar, Kyle Hedin, Maryam Raeeszadeh-Sarmazdeh

Journal: Protein Sci

PubMed ID: 37807423

Doi: 10.1002/pro.4795

Products & Services: Proteins, Expression, Isolation and Analysis

Novel SOX10 indel mutations drive schwannomas through impaired transactivation of myelination gene programs

Authors: Erik A Williams, Ajay Ravindranathan, Rohit Gupta, Nicholas O Stevers, Abigail K Suwala, Chibo Hong, Somang Kim, Jimmy Bo Yuan, Jasper Wu, Jairo Barreto, Calixto-Hope G Lucas, Emily Chan, Melike Pekmezci, Philip E LeBoit, Thaddeus Mully, Arie Perry, Andrew Bollen, Jessica Van Ziffle, W Patrick Devine, Alyssa T Reddy, Nalin Gupta, Kristen M Basnet, Robert J B Macaulay, Patrick Malafronte, Han Lee, William H Yong, Kevin Jon Williams, Tareq A Juratli, Douglas A Mata, Richard S P Huang, Matthew C Hiemenz, Dean C Pavlick, Garrett M Frampton, Tyler Janovitz, Jeffrey S Ross, Susan M Chang, Mitchel S Berger, Line Jacques, Jun S Song, Joseph F Costello, David A Solomon

Journal: Neuro Oncol

PubMed ID: 37436963

Doi: 10.1093/neuonc/noad121

Products & Services: Proteins, Expression, Isolation and Analysis

Ubiquitin-specific protease 22 promotes tumorigenesis and progression by an FKBP12/mTORC1/autophagy positive feedback loop in hepatocellular carcinoma

Authors: Qianwei Ye, Wei Zhou, Shengjun Xu, Qingyang Que, Qifan Zhan, Lincheng Zhang, Shusen Zheng, Sunbin Ling, Xiao Xu

Journal: MedComm (2020)

PubMed ID: 38045832

Doi: 10.1002/mco2.439

Products & Services: Proteins, Expression, Isolation and Analysis

Authors: Ewa Hordyjewska-Kowalczyk, Wim Wuyts, Nele Boeckx, An Verdonck, Gretl Hendrickx, Geert Mortier

Journal: Clin Genet

PubMed ID: 38108099

Doi: 10.1111/cge.14474

Products & Services: Proteins, Expression, Isolation and Analysis

The nuclease-associated short prokaryotic Argonaute system nonspecifically degrades DNA upon activation by target recognition

Authors: Xueling Lu, Jun Xiao, Longfei Wang, Bin Zhu, Fengtao Huang

Journal: Nucleic Acids Res

PubMed ID: 38048327

Doi: 10.1093/nar/gkad1145

Products & Services: Proteins, Expression, Isolation and Analysis

The global transcription regulator XooClp governs Type IV pili system mediated bacterial virulence by directly binding to their promoters to coordinate virulence associated functions

Authors: Raj Kumar Verma, Parimala Gondu, Tirthankar Saha, Subhadeep Chatterjee

Journal: Mol Plant Microbe Interact

PubMed ID: 38105438

Doi: 10.1094/MPMI-07-23-0100-R

Products & Services: Proteins, Expression, Isolation and Analysis

RIF1 regulates early replication timing in murine B cells

Authors: Daniel Malzl, Mihaela Peycheva, Ali Rahjouei, Stefano Gnan, Kyle N Klein, Mariia Nazarova, Ursula E Schoeberl, David M Gilbert, Sara C B Buonomo, Michela Di Virgilio, Tobias Neumann, Rushad Pavri

Journal: Nat Commun

PubMed ID: 38081811

Doi: 10.1038/s41467-023-43778-y

Products & Services: Proteins, Expression, Isolation and Analysis

Differential activation of mouse and human Panx1 channel variants

Authors: Antonio Cibelli, Preeti Dohare, David C Spray, Eliana Scemes

Journal: PLoS ONE

PubMed ID: 38100403

Doi: 10.1371/journal.pone.0295710

Products & Services: Proteins, Expression, Isolation and Analysis

Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455-456 synergistically enhances antibody evasion and ACE2 binding

Authors: Fanchong Jian, Leilei Feng, Sijie Yang, Yuanling Yu, Lei Wang, Weiliang Song, Ayijiang Yisimayi, Xiaosu Chen, Yanli Xu, Peng Wang, Lingling Yu, Jing Wang, Lu Liu, Xiao Niu, Jing Wang, Tianhe Xiao, Ran An, Yao Wang, Qingqing Gu, Fei Shao, Ronghua Jin, Zhongyang Shen, Youchun Wang, Xiangxi Wang, Yunlong Cao

Journal: PLoS Pathog

PubMed ID: 38117863

Doi: 10.1371/journal.ppat.1011868

Products & Services: Proteins, Expression, Isolation and Analysis

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