目录产品 » HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer, His & Avi, Rhesus macaque
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HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer, His & Avi, Rhesus macaque

HLA-G is a molecule that was first known to confer protection to the fetus from destruction by the immune system of its mother, thus critically contributing to fetal-maternal tolerance. The first functional finding constituted the basis for HLA-G research and can be summarized as such: HLA-G, membrane-bound or soluble, strongly binds its inhibitory receptors on immune cells (NK, T, B, monocytes/dendritic cells), inhibits the functions of these effectors, and so induces immune inhibition.
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Z06679-100

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产品简介
Species Rhesus macaque
Protein Construction
HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer [Gly25-Thr305(HLA-G), Ile21-Met119(B2M) and RIIPRHLQL peptide]
Accession # O02948(HLA-G)&Q6V7J5(B2M)&RIIPRHLQL		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 258 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 260-265 kDa under Non reducing (N) condition based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer, His & Avi, Rhesus Macaque

Immobilized HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer, His & Avi, Rhesus macaque, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Rhesus macaque LILRB1, hFc Tag with the EC50 of 102 ng/ml determined by ELISA. »

HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer, His & Avi, Rhesus Macaque

The purity of HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer, His & Avi, Rhesus macaquer is greater than 95% as determined by SEC-HPLC. »

HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer, His & Avi, Rhesus Macaque

HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer, His & Avi, Rhesus macaque on Bis-Tris PAGE under Non reducing (N) condition. The purity is greater than 95%. »

HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer, His & Avi, Rhesus Macaque

Rhesus macaque LILRB1, hFc Tag captured on CM5 Chip via Protein A can bind HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer, His & Avi, Rhesus macaque, His Tag with an affinity constant of 1.74 nM as determined in SPR assay (Biacore T200). »

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技术背景
Target Background HLA-G is a molecule that was first known to confer protection to the fetus from destruction by the immune system of its mother, thus critically contributing to fetal-maternal tolerance. The first functional finding constituted the basis for HLA-G research and can be summarized as such: HLA-G, membrane-bound or soluble, strongly binds its inhibitory receptors on immune cells (NK, T, B, monocytes/dendritic cells), inhibits the functions of these effectors, and so induces immune inhibition.
Synonyms HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.