目录产品 » HLA-A*11:01&B2M&LMP2 (SSCSSCPLTK) Monomer, His & Avi, Human
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HLA-A*11:01&B2M&LMP2 (SSCSSCPLTK) Monomer, His & Avi, Human

The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of malignant tumors that highly express LMP2.
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Z06632-100

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产品简介
Species Human
Protein Construction
HLA-A*11:01&B2M&LMP2 (SSCSSCPLTK) Monomer[Gly25-Thr305(HLA-A*11:01), Ile21-Met119(B2M) and SSCSSCPLTK peptide]
Accession # AAV53343.1(HLA-A*11:01)&P61769(B2M)&SSCSSCPLTK		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 50.4 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 51-60 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
HLA-A*11:01&B2M&LMP2 (SSCSSCPLTK) Monomer, His & Avi, Human

The purity of HLA-A*11:01&B2M&LMP2 (SSCSSCPLTK) Monomer, His & Avi, Human is greater than 95% as determined by SEC-HPLC. »

HLA-A*11:01&B2M&LMP2 (SSCSSCPLTK) Monomer, His & Avi, Human

HLA-A*11:01&B2M&LMP2 (SSCSSCPLTK) Monomer, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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技术背景
Target Background The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of malignant tumors that highly express LMP2.
Synonyms MHC; RMF; LMP2; LMP-2; Macropain chain 7; Proteasome chain 7; PSMB9; RING12
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.